Diana Bishop is a brilliant historian who is also a reluctant witch in denial of her heritage. When she finds a manuscript in Oxford's Bodleian Library, its sets her on the path of a dangerous mystery.

Teaming up with geneticist Matthew Clairmont, who is an ancient vampire hiding his own dark family secrets, the two work to understand the meaning of the manuscript despite an age-old mistrust between witches and vampires.

But as their relationship develops and their heritage comes in to play, events occur that threaten to unravel the fragile peace that has long-existed between humans, witches, vampires, and demons.

Adapted from the best-selling novel by Deborah Harkness.