Dr. George Coleman is an ace veterinarian who has an impressive list of "famous" animal patients at his New York veterinary clinic - a place where it's almost as if the patients are the actual ones running the place. George brings his unorthodox style and undeniable gift to work with him every day, where he deals with animals of all kinds.

But much to his dismay, George has recently found out that his ex-girlfriend has inherited the family business - making her George's boss. Intelligent and ambitious, Dorothy wants to shake things up at the hospital by restoring order to the chaos - but not without clashing with George's animal-friendly administrative staff.