Dr. Amy Larsen is the brilliant Chief of Internal and Family Medicine at Westside Hospital in Minneapolis. After a brain injury erases the last eight years of her life, Amy is left to navigate an unfamiliar world where she has no recollection of patients she's treated, colleagues she's crossed, the soulmate she divorced, the man she now loves, or the tragedy that caused her to push everyone away.

She can only rely on her estranged 17-year-old daughter, whom she remembers as a 9-year-old, and a few loyal friends, as she struggles to continue practicing medicine, despite having lost nearly a decade of knowledge and experience.