Over a long weekend, John and Marlena travel to Zurich, Ben and Ciara take a romantic trip to New Orleans, Chad visits old friends in Phoenix, and Abe, Paulina, Lani, and Eli vacation in Miami.

All of them become involved in a mystery involving stolen jewels, which could result in dire consequences for Salem if they end up in the wrong hands. ISA agent Billie Reed must race against the clock as she traverses the globe in search of the missing treasure.