Season 1 focuses on Dr. Christopher Duntsch, a charismatic and ostensibly brilliant rising star in the Dallas medical community. His growing neurosurgery practice started to crumble when many of his patients left his operating room permanently maimed or dead.

Season 2 is based on the Wondery podcast, following "Miracle Man" Paolo Macchiarini, a charming surgeon renowned for his innovative operations but will go to any lengths to protect his secrets.